IU1

• Background :

  Selective inhibitor of Usp14 (IC50<4 μM) . Enhances proteasome activity and substrate proteolysis.1,2 Inhibits Dengue virus replication.3 In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load.4 Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model.5 Cell permeable.

• Conjugation :

  Unconjugated

• Buffer :

  Beige solid

• Storage Conditions :

  -20°C