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A-769662

CAT: 0498-bs-82110C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82110C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the  and  subunits and not the AMP binding site1. EC50=0.8 M for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 M2. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation3. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming4. Synergizes with AICAR5. Cell permeable.
Conjugation
Unconjugated
Buffer
Beige solid
Storage Conditions
-20°C

Alternative Products

CatalogName
A3963-5.1A-769662
SIH-490-5MGA 769662

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