AP-18

• Background:

  TRPA1 channel blocker IC50=3.1-4.5 μM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 μM.1 Blocks TRPA1 pore dilation (IC50=10.3 μM) .2 An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.3-5

• Conjugation:

  Unconjugated

• Buffer:

  White solid

• Storage Conditions:

  RT