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EZH2 Antibody

CAT: 0800-F53753-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#: F53753-0.08MLSize: 0.08 mL
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EZH2, SUZ12, and EED form a complex that methylates nucleosomal histone H3 at Lys27. EZH2 contains a SET domain, a signature motif for all known histone lysine methyltransferases except the H3-K79 methyltransferase DOT1, and is therefore likely to be the catalytic subunit. Consequently, EZH2 is thought to regulate gene expression by controlling chromatin structure. Several lines of evidence suggested a critical role for the EZH2 protein during normal and perturbed development of the hematopoietic and central nervous systems. The EZH2 protein has been shown to associate with the VAV1 protooncoprotein and with the XNP protein, the product of a gene associated with mental retardation. Additionally, due to mapping of EZH2 to the 7q35-q36 chromosomal region associated with myeloid disorders, this protein is suggested to participate in the genetic events triggering myeloid leukemia.
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q15910
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This EZH2 antibody was produced from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human EZH2.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Limitations
This EZH2 antibody is available for research use only.
Storage Conditions
Aliquot the EZH2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the EZH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Primate, Xenopus
Image Legend
Western blot testing of EZH2 antibody at 1:1000 dilution + rat C6 lysate; Predicted size : 85-95 kDa.

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