TERT Antibody

CAT: 0800-F54238-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F54238-0.4MLSize:0.4 mL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
Specifications
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:25-1:50, Flow cytometry: 1:25 (1x10e6 cells), Immunofluorescence: 1:25
UniProt
O14746
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 1104-1132 from the human protein were used as the immunogen for the TERT antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, FACS, IF
Purity
Antigen affinity purified
Format
Purified
Limitations
This TERT antibody is available for research use only.
Storage Conditions
Aliquot the TERT antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the TERT antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot testing of human 1) Raji and 2) HL60 cell lysate with TERT antibody. Predicted molecular weight: 120-126 kDa (two isoforms may be visualized) .

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