GREM1 Antibody / Gremlin 1

• Description:

  GREM1, also referred to as Gremlin 1, is a protein that plays a crucial role in a variety of biological processes, ranging from embryonic development to cancer progression. This multifunctional protein is a member of the BMP (Bone Morphogenetic Protein) antagonist family and is known for its ability to regulate cell growth, differentiation, and survival. One of the most intriguing aspects of GREM1 is its role in embryonic development. Studies have shown that this protein is essential for proper development of various tissues and organs, such as the lung, kidney, and limb. Additionally, GREM1 has been implicated in the formation of certain structures in the developing embryo, highlighting its importance in shaping the body's overall architecture. In addition to its role in embryonic development, GREM1 has also been linked to various diseases, particularly cancer. Research has shown that abnormal levels of Gremlin 1 are associated with tumor growth, invasion, and metastasis in several types of cancer, including colorectal, ovarian, and pancreatic cancer. This suggests that targeting GREM1 could potentially be a novel strategy for combating cancer progression. GREM1 has recently gained attention for its potential as a therapeutic target in certain diseases.

• Specifications:

  Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:50-1:100

• UniProt:

  O70326

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  A portion of amino acids 147-175 from the human protein was used as the immunogen for the GREM1 antibody.

• Clonality:

  Polyclonal

• Isotype:

  Ig

• Applications:

  WB, IHC-P

• Purity:

  Antigen affinity

• Format:

  Purified

• Limitations:

  This GREM1 antibody is available for research use only.

• Storage Conditions:

  Aliquot the GREM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  The stated application concentrations are suggested starting points. Titration of the GREM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• Image Legend:

  IHC staining of FFPE mouse spleen tissue with GREM1 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.