ORMDL3 Antibody / ORM1-like protein 3

CAT: 0800-F55101-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F55101-0.08MLSize:0.08 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ORM1-like protein 3 is a protein that is encoded by the ORMDL3 gene. It belongs to a family of proteins known as ORM proteins, which play a crucial role in regulating the levels of sphingolipids - a class of lipids that are involved in various cellular processes. In particular, ORMDL3 has been shown to be a key player in the regulation of sphingolipid synthesis, and aberrant expression of this protein has been implicated in a number of diseases, including asthma. Recent studies have revealed that ORMDL3 plays a critical role in the development of asthma. It has been shown that individuals with certain genetic variations that result in increased ORMDL3 expression are at a higher risk of developing asthma. Additionally, ORMDL3 has been shown to be involved in the regulation of immune responses in the lungs, with increased levels of this protein leading to inflammation and airway hyperreactivity - hallmark features of asthma.
Specifications
Western blot: 1:500-1:1000
UniProt
Q8N138
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 53-81 from the human protein was used as the immunogen for the ORMDL3 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB
Purity
Antigen affinity
Format
Purified
Limitations
This ORMDL3 antibody is available for research use only.
Storage Conditions
Aliquot the ORMDL3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the ORMDL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of 1) human Jurkat and 2) mouse testis tissue lysate with ORMDL3 antibody. Predicted molecular weight ~17 kDa.

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