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Bax Antibody

CAT: 0800-R30183Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30183Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bcl-2 Associated X Protein is a member of the Bcl-2 gene family. The gene encodes a 21-kDa protein whose association with Bcl-2 is believed to play a critical role in regulating apoptosis. It is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. It resides in an inactive state in the cytosol of many cells. Bax consists of 9 alpha helices and has extensive amino acid homology with Bcl-2, focused within highly conserved domains I and II. The protein is encoded by six exons and demonstrates a complex pattern of alternative RNA splicing that predicts a 21 kd membrane (alpha) and two forms of cytosolic protein (beta and gamma) . Bax and Bak are essential for regulating the number of B cells at both immature and mature developmental stages. They are critical mediators of B cell death induced by multiple stimuli.
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/10^6 cells, Immunohistochemistry (FFPE) : 2-5 µg/mL
UniProt
Q07812
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 19-33 (IMKTGALLLQGFIQD) were used as the immunogen for this Bax antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Limitations
This Bax antibody is available for research use only.
Storage Conditions
After reconstitution, the Bax antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Bax antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Bax antibody and Lane 1: rat testis; 2: rat kidney; 3: (r) brain; 4: (r) ovary; 5: human HeLa; 6: (h) MM231; 7: (h) A549; 8: (h) Jurkat; 9: (h) placenta tissue lysate. Predicted molecular weight: 21-24 kDa.

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