Products for Research Use Only
RegisterLogin

Desmoglein 2 Antibody

CAT: 0800-R30636Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-R30636Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, Immunofluorescence: 2-4 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
Q14126
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human Desmoglein 2 (STRVTKHSTVQHSYS) was used as the immunogen for this Desmoglein 2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Limitations
This Desmoglein 2 antibody is available for research use only.
Storage Conditions
After reconstitution, the Desmoglein 2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Desmoglein 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasm, membrane (cell junctions)
Image Legend
Immunofluorescent staining of FFPE human MCF7 cells with Desmoglein 2 antibody (green) and DAPI (blue) .

UniProtKB · Q14126

Desmoglein-2

DSG2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14126
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DSG2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q4KKU6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Disease

CardiomyopathyDisease variant

Biological process

Cell adhesion

Cellular component

Cell junctionCell membraneCytoplasmMembraneSecreted

PTM

Cleavage on pair of basic residuesGlycoproteinLipoproteinPalmitatePhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

Related Products

CatalogName
V3289-100UGDSG2 Antibody / Desmoglein 2
V3289SAF-100UGDSG2 Antibody / Desmoglein 2
RQ7648DSG2 Antibody / Desmoglein 2
V3289-20UGDSG2 Antibody / Desmoglein 2
V3266-100UGDesmoglein Antibody
V3266SAF-100UGDesmoglein Antibody
V3266-20UGDesmoglein Antibody
R36403-100UGDesmoglein 1 Antibody
V4573-20UGDesmoglein-3 Antibody
R30643Desmoglein 3 Antibody

Alternative Products

CatalogName
10R-D106aDesmoglein 2 antibody
70R-51195Desmoglein 4 antibody
10R-D104bDesmoglein 1 antibody
MBS8580534-01Desmoglein 3 Antibody
MBS4162583-01Anti-Desmoglein Antibody
KC-27642-01Desmoglein-2 Antibody
GTR18205262-01Desmoglein-3 Antibody
GWB-D7EC58DESMOGLEIN 1, Antibody
GWB-169980Desmoglein 2, Antibody
216452Desmoglein 2 (Desmoglein-2, DSG2)

Popular Products