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TFPI2 Antibody

CAT: 0800-RQ8857Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ8857Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tissue factor pathway inhibitor 2, also known as TFPI2, is a human gene which is located at 7q22. It is an important regulator of the extrinsic pathway of blood coagulation through its ability to inhibit factor Xa and factor VIIa-tissue factor activity. After a 22-residue signal peptide, the mature TFPI2 protein contains 213 amino acids with 18 cysteines and 2 canonical N-linked glycosylation sites. The purified recombinant TFPI2 strongly inhibited the amidolytic activities of trypsin and the factor VIIa-tissue factor complex. The latter inhibition was markedly enhanced in the presence of heparin. Mouse TFPI2 mRNA is highly expressed in developing mouse placenta, as in human. And there are also high transcript levels in adult mouse liver and kidney.
Specifications
Western blot: 1-2 µg/mL, ELISA: 0.1-0.5 µg/mL
UniProt
P48307
Host
Rabbit
Reactivity
Human, Rat
Immunogen
An E.coli-derived human recombinant protein (amino acids E70-Q105) was used as the immunogen for the TFPI2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, ELISA
Purity
Antigen affinity chromatography
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Limitations
This TFPI2 antibody is available for research use only.
Storage Conditions
After reconstitution, the TFPI2 Antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the TFPI2 antibody should be determined by the researcher.

UniProtKB · P48307

Tissue factor pathway inhibitor 2

TFPI2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P48307
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TFPI2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TFPI-2
EC number
—
Processing
Precursor
Secondary accessions
Q66ME8, Q8NAK6, Q9UC86
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Blood coagulationHemostasis

PTM

Disulfide bondGlycoprotein

Molecular function

Protease inhibitorSerine protease inhibitor

Domain

RepeatSignal

Cellular component

Secreted

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