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Podoplanin Antibody

CAT: 0800-V5650-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V5650-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Podoplanin is a transmembrane mucoprotein (38 kDa) recognized by the D2-40 monoclonal antibody. Podoplanin is specifically expressed in the endothelium of lymphatic capillaries but not in the blood vasculature. In normal skin and kidney, podoplanin is co-localized with VEGFR3/FLT4, another marker for lymphatic endothelial cells. Podoplanin is selectively expressed in lymphatic endothelium as well as Lymphangiomas, Kaposi’s Sarcomas and in subset Angiosarcomas with probable lymphatic differentiation. Podoplanin has also been shown to be expressed in Epithelioid Mesotheliomas, Hemangioblastomas and Seminomas.
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q86YL7
Host
Mouse
Reactivity
Human
Immunogen
Resected tissue from dysgeminoma of the ovary was used as the immunogen for the Podoplanin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
D2-40
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Limitations
This Podoplanin antibody is available for research use only.
Storage Conditions
Aliquot the Podoplanin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Podoplanin antibody should be determined by the researcher.
Location
Cytoplasm, Membrane
Image Legend
IHC staining of FFPE human tonsil tissue with Podoplanin antibody (clone D2-40) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q86YL7

Podoplanin

PDPN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86YL7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDPN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A9Z1Y2, B2R6J8, E9PB68, F6QWX5, O60836, O95128, Q7L375, Q8NBQ8, Q8NBR3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneCell projectionCytoplasmMembrane

Biological process

Cell shape

Molecular function

Developmental protein

PTM

Glycoprotein

Ligand

Sialic acid

Domain

SignalTransmembraneTransmembrane helix

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