CETN1 Antibody / Centrin 1

• Description:

  EF-hand type Ca2+-binding proteins consists of several family members, including Centrin-1, Centrin-2 and Centrin-3. The Centrin proteins are ubiquitously expressed cytoskeletal components that show increased expression during cell differentiation. Tissues where cilia are present, such as the retina and testis, express both Centrin-1 and -2, but Centrin-2 is also expressed in nondifferentiated, nonciliated retinal cells (retinoblastoma cells), liver, skeletal muscle, and cardiac muscle. In these tissues, Centrin associates with the centrosomes, mitotic spindle poles, and basal bodies. Knockdown studies reveal a requirement for Centrin in centriole duplication and organization of spindle pole morphology and the completion of cytokinesis. Centrin-3 plays a role in centrosome reproduction.

• Specifications:

  Immunohistochemistry (FFPE) : 1-2 µg/mL

• UniProt:

  Q12798

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  A portion of amino acids 1-172 from human CETN1 protein was used as the immunogen for the CETN1 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG

• Clone:

  CETN1/9878

• Applications:

  IHC-P

• Purity:

  Protein A/G affinity

• Format:

  Purified

• Limitations:

  This CETN1 antibody is available for research use only.

• Storage Conditions:

  Aliquot the CETN1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

• Applications Notes:

  Optimal dilution of the CETN1 antibody should be determined by the researcher.

• Location:

  Cell projection, Cytoplasm, Nucleus

• Image Legend:

  SDS-PAGE analysis of purified, BSA-free CETN1 antibody (clone CETN1/9878) as confirmation of integrity and purity.