17-beta-HSD 13 Antibody / HSD17B13

• Description:

  Hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13, 17-beta-HSD 13) is an enzyme in the liver that is associated with lipid droplets. It is encoded by the HSD17B13 gene in humans. HSD17B13 levels increase in patients with non-alcoholic fatty liver disease (NAFLD) and can enhance lipogenesis. However, some studies have shown that loss-of-function variants in HSD17B13 may protect against the progression of NAFLD to non-alcoholic steatohepatitis, fibrosis, and hepatocellular carcinoma.

• Specifications:

  Immunohistochemistry (FFPE) : 1-2 µg/mL

• UniProt:

  Q7Z5P4

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  A portion of amino acids 1-200 of the human protein was used as the immunogen for the 17-beta-HSD 13 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG2b κ

• Clone:

  HSD17B13/13104

• Applications:

  IHC-P

• Purity:

  Protein G affinity

• Format:

  Purified

• Limitations:

  This 17-beta-HSD 13 antibody is available for research use only.

• Storage Conditions:

  Aliquot the 17-beta-HSD 13 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

• Applications Notes:

  Optimal dilution of the 17-beta-HSD 13 antibody should be determined by the researcher.

• Location:

  Cytoplasm

• Image Legend:

  IHC staining of FFPE human hepatocellular carcinoma tissue with 17-beta-HSD 13 antibody (clone HSD17B13/13104) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.