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Fibronectin Antibody

CAT: 0800-V7408-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7408-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fibronectins are disulfide-linked, dimeric glycoproteins of ~440kDa. They possess at least four binding sites for collagen, glycosaminoglycans, transglutaminase, and a cell surface receptor. Fibronectins are involved in cell adhesion, tissue organization, and wound healing. Fibronectins are present in basement membranes, interstitial connective tissue matrix, and blood. Cellular fibronectin is widely distributed in the stroma of many malignant tumors. This mAb does not cross-react with MMP-2, MMP-9, or TIMP-2.
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
UniProt
P02751
Host
Mouse
Reactivity
Human
Immunogen
High molecular weight proteins secreted by cultivated human fibroblasts were used as the immunogen for the Fibronectin antibody. The epitope of this mAb is located in the 29kDa N-terminal fibrin- and heparin-binding domain of fibronectin.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
616
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Limitations
This Fibronectin antibody is available for research use only.
Storage Conditions
Store the Fibronectin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Connective tissue matrix
Image Legend
IHC staining of FFPE human prostate carcinoma with Fibronectin antibody (clone 616) . HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min followed by cooling prior to testing.

UniProtKB · P02751

Fibronectin

FINC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02751
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
FN
EC number
—
Processing
Precursor
Secondary accessions
B7ZLF0, E9PE77, E9PG29, O95609, O95610, Q14312, Q14325, Q14326, Q17RV7, Q53S27, Q564H7, Q585T2, Q59EH1, Q60FE4, Q68DP8, Q68DP9, Q68DT4, Q6LDP6, Q6MZS0, Q6MZU5, Q6N025, Q6N0A6, Q7Z391, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Acute phaseAngiogenesisCell adhesionCell shape

Coding sequence diversity

Alternative splicing

Disease

Disease variantDwarfism

PTM

Disulfide bondGlycoproteinIsopeptide bondOxidationPhosphoproteinPyrrolidone carboxylic acidSulfation

Cellular component

Extracellular matrixSecreted

Molecular function

Heparin-binding

Domain

RepeatSignal

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