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Anti-Mnk2a Antibody

CAT: 0942-1180-Mnk2aSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0942-1180-Mnk2aSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAP kinase-interacting kinases Mnk1 and Mnk2 are activated by the MAP kinases, ERK and p38 (Waskiewicz et al., 1997) . Additionally, Mnk1 and Mnk2 have been shown to phosphorylate the translation initiation factor eIF4E (Fukunaga and Hunter 1997; Waskiewicz et al., 1997) . Alternative splicing of the MKNK2 gene results in two isoforms with different C-termini: one that has a MAPK-binding domain, Mnk2a, and one that does not, Mnk2b (Parra et al., 2005) . Recent studies have indicated that Mnk2a has tumor suppressive activity while Mnk2b is pro-oncogenic (Maimon et al., 2014) .
Description
Our Anti-Mnk2a rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Mnk2a and is antigen affinity purified from pooled serum. It is great for use in WB.
Synonyms
ADCAD1 antibody, MADS box transcription enhancer factor 2 polypeptide A (myocyte enhancer factor 2A) antibody, MEF2 antibody, MEF2A antibody, MEF2A_HUMAN antibody, Myocyte enhancer factor 2A antibody, Myocyte-specific enhancer factor 2A antibody, RSRFC4 antibody, RSRFC9 antibody, Serum response factor like protein 1 antibody, Serum response factor-like protein 1 antibody
Other Statements
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Gene Name
MKNK2
NCBI Gene ID
2872
UniProt
Q9HBH9
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide from the C-terminal region, specific to the human Mnk2a isoform. The sequence of the antigen has no homology with Mnk1 or Mnk2b.
Immunogen Type
Human
Target
Mnk2a
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
ELISA, WB
Concentration
Lot Dependent
Format
Antigen Affinity Purified from Pooled Serum
Form
Liquid
Buffer
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Molecular Weight
47
Shipping Conditions
Blue Ice
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
WB Dilution
1:500
Specificity
Specific for endogenous levels of the ~52 kDa Mnk2a protein. Immunolabeling is blocked by preadsorption with the Mnk2a peptide used as antigen, but not by Mnk2b peptide.
Formulation
Prepared from pooled rabbit serum by affinity purification via chromatography on peptide immunogen column.
Quality Control
Western blots performed on each lot.
Species
Non-Human Primate
Isotype
IgG

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