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Anti-eEF1A2 (Ser358) Antibody

CAT: 0942-p153-358Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0942-p153-358Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Eukaryotic Elongation Factor eEF1A exists in two variant forms, eEF1A1 and eEF1A2. While eEF1A1 is almost ubiquitously expressed in humans, eEF1A2 is predominantly found in heart, brain, and skeletal muscle (Knudsen et al., 1993) . Expression of eEF1A2 may have a role in ovarian cancer, as its expression is drastically increased in human ovarian tumors (Anand et al., 2002) . Due to differences in structural models between the two isoforms, eEF1A1 and eEF1A2 likely have variant-specific phosphorylation sites (Soares et al., 2009) . Ribosome-associated JNK phosphorylates Ser-358 on eEF1A2 to promote degradation of newly synthesized polypeptides by the proteasome (Gandin et al., 2013) .
Description
Our Anti-eEF1A2 (Ser358) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects human and mouse eEF1A2 (Ser358) and is antigen affinity purified from pooled serum. It is great for use in WB.
Synonyms
EEF1A-2 antibody, Eef1a2 antibody, EEF1AL antibody, EF 1 alpha 2 antibody, EF-1-alpha-2 antibody, EF1A antibody, EF1A2_HUMAN antibody, Elongation factor 1 A 2 antibody, Elongation factor 1 alpha antibody, Elongation factor 1 alpha 2 antibody, Elongation factor 1-alpha 2 antibody, Eukaryotic elongation factor 1 A-2 antibody, Eukaryotic translation elongation factor 1 alpha 2 antibody, FLJ41696 antibody, HS1 antibody, OTTHUMP00000031776 antibody, Statin like antibody, Statin S1 antibody, Statin-S1 antibody, STN antibody, STNL antibody
Other Statements
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Gene Name
EEF1A2
NCBI Gene ID
1917
UniProt
Q05639
Modification Site
Ser358
Host
Rabbit
Reactivity
Human and Mouse
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser358 of human eEF1A2, conjugated to keyhole limpet hemocyanin (KLH) .
Immunogen Type
Human
Target
EEF1A2 (Ser358)
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
ELISA, WB
Concentration
Lot Dependent
Format
Antigen Affinity Purified from Pooled Serum
Form
Liquid
Buffer
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Modification
Phosphorylated
Molecular Weight
50
Shipping Conditions
Blue Ice
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
WB Dilution
1:1000
Specificity
Specific for endogenous levels of the ~50 kDa eEF1A2 phosphorylated at Ser358. Immunolabeling is completely eliminated by treatment with λ-phosphatase.
Formulation
Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.
Quality Control
Western blots performed on each lot.
Species
Chicken, Non-Human Primate, Rat, Sheep, Xenopus
Isotype
IgG

UniProtKB · Q05639

Elongation factor 1-alpha 2

EF1A2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q05639
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EEF1A2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
EF-1-alpha-2
EC number
3.6.5.-
Processing
—
Secondary accessions
B5BUF3, E1P5J1, P54266, Q0VGC7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoprotein

Disease

Autism spectrum disorderDisease variantEpilepsyIntellectual disability

Molecular function

Elongation factorHydrolase

Cellular component

Endoplasmic reticulumMembrane

Ligand

GTP-bindingMagnesiumMetal-bindingNucleotide-binding

Biological process

Protein biosynthesis

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