C16-Ceramide

• UNSPSC Description:

  C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding[1].

• Target Antigen:

  Apoptosis; Endogenous Metabolite; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/c16-ceramide.html

• Purity:

  99.0

• Solubility:

  DMF : 20 mg/mL (ultrasonic;warming;heat to 60°C)|DMSO : < 1 mg/mL (ultrasonic)|Ethanol : 20 mg/mL (warming;heat to 60°C)

• Smiles:

  CCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O

• Molecular Weight:

  537.90

• References & Citations:

  [1]Fekry B, et al. C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Nat Commun. 2018 Oct 8;9(1):4149.|[2]Rénert AF, et al. The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells. J Proteome Res. 2009 Oct;8(10):4810-22.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  24696-26-2