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Coelonin

CAT: 0804-HY-N8884-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8884-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein[1][2].
CAS Number
82344-82-9
UNSPSC
12352005
Hazard Statement
H410
Target
Akt; Interleukin Related; NF-κB; PTEN; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/coelonin.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
OC(C=C1CC2)=CC(OC)=C1C3=C2C=C(O)C=C3
Molecular Formula
C15H14O3
Molecular Weight
242.27
Precautions
H410
References & Citations
[1]Jiang F, et al. Coelonin, an Anti-Inflammation Active Component of Bletilla striata and Its Potential Mechanism. Int J Mol Sci. 2019 Sep 8;20 (18) :4422.|[2]Cheng W, et al. Inhibition of inflammation-induced injury and cell migration by coelonin and militarine in PM2.5-exposed human lung alveolar epithelial A549 cells. Eur J Pharmacol. 2021 Apr 5;896:173931.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Akt; IL-1; IL-6; NF-κB

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