CDH1 Mouse Monoclonal Antibody

• Background:

  E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.

• Product Name Alternative:

  UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1; E-cadherin; E cadherin

• Gene Name:

  CDH1

• Gene ID:

  999

• Swiss Prot:

  P12830

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Monkey

• Clonality:

  Monoclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, ELISA, FC

• Field of Research:

  TGF-beta signaling pathway

• Purification:

  Affinity Purification

• Dilution:

  WB 1:500-1:2000, IHC 1:200-1:1000, ELISA 1:5000-1:20000, FC 1:200-1:400

• Form:

  Liquid

• Buffer:

  Purified antibody in PBS with 0.05% sodium azide.

• Modification:

  Unmodified

• Molecular Weight:

  135kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Isotype:

  Mouse IgG1