KI2LA Rabbit Polyclonal Antibody

• Background:

  Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A (KIR2DL5A) Homo sapiens Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) . The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack thefunction:Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis., similarity:Belongs to the immunoglobulin superfamily., similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

• Gene Name:

  KIR2DL5A CD158F CD158F1 KIR2DL5

• Gene ID:

  57292

• Swiss Prot:

  Q8N109

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, ELISA

• Field of Research:

  Antigen processing and presentation; Natural killer cell mediated cytotoxicity; Graft-versus-host disease

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, ELISA 1:5000-1:20000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  41kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG