CyPB Rabbit Polyclonal Antibody

• Background :

  The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009], catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0) ., caution:It is uncertain whether Met-1 or Met-9 is the initiator., enzyme regulation:Cyclosporin A (CsA) inhibits CYPB., function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily., similarity:Contains 1 PPIase cyclophilin-type domain., subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

• Product Name Alternative :

  PPIB; CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP

• Gene Name :

  PPIB

• Gene ID :

  5479

• Swiss Prot :

  P23284

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB, ELISA

• Purification :

  Affinity purification

• Dilution :

  WB 1:500-1:2000, ELISA 1:10000-1:20000

• Form :

  Liquid

• Buffer :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification :

  Unmodified

• Molecular Weight :

  24kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype :

  IgG