MLL2 Rabbit Polyclonal Antibody

CAT: 1444-APRab13960-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab13960-01Size:20 µL
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Background
The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010], catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N (6) -methyl-L-lysine., domain:LXXLL motifs 5 and 5 are essential for the association with ESR1 nuclear receptor., function:Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription., miscellaneous:This gene mapped to a chromosomal region involved in duplications and translocations associated with cancer., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily., similarity:Contains 1 post-SET domain., similarity:Contains 1 RING-type zinc finger., similarity:Contains 1 SET domain., similarity:Contains 5 PHD-type zinc fingers., subunit:Component of the MLL2/MLL3 complex (also named ASCOM complex), at least composed of MLL2, MLL3, ASH2L, RBBP5, DPY30, NCOA6, WDR5, MEN1, KDM6A and PAXIP1/PTIP. Interacts with NFE2. Interacts with ESR1; interaction is direct., tissue specificity:Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.
Gene Name
MLL2 ALR KMT2D MLL4
Gene ID
8085
Swiss Prot
O14686
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF
Purification
Affinity purification
Dilution
IHC 1:50-1:300, ICC/IF 1:50-1:200
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
609kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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