MLL2 Rabbit Polyclonal Antibody

• Background:

  The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010], catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N (6) -methyl-L-lysine., domain:LXXLL motifs 5 and 5 are essential for the association with ESR1 nuclear receptor., function:Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription., miscellaneous:This gene mapped to a chromosomal region involved in duplications and translocations associated with cancer., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily., similarity:Contains 1 post-SET domain., similarity:Contains 1 RING-type zinc finger., similarity:Contains 1 SET domain., similarity:Contains 5 PHD-type zinc fingers., subunit:Component of the MLL2/MLL3 complex (also named ASCOM complex), at least composed of MLL2, MLL3, ASH2L, RBBP5, DPY30, NCOA6, WDR5, MEN1, KDM6A and PAXIP1/PTIP. Interacts with NFE2. Interacts with ESR1; interaction is direct., tissue specificity:Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.

• Gene Name:

  MLL2 ALR KMT2D MLL4

• Gene ID:

  8085

• Swiss Prot:

  O14686

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  IHC, ICC/IF

• Purification:

  Affinity purification

• Dilution:

  IHC 1:50-1:300, ICC/IF 1:50-1:200

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  609kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG