Fish Rabbit Polyclonal Antibody

CAT: 1444-APRab10993-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab10993-01Size:20 µL
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Background
Domain:The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19., domain:The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns (3) P) and phosphatidylinositol 3,4-biphosphate (PtdIns (3,4) P2) ., function:Required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns (3) P) and phosphatidylinositol 3,4-biphosphate (PtdIns (3,4) P2) . In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide., PTM:Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR., similarity:Belongs to the SH3PXD2 family., similarity:Contains 1 PX (phox homology) domain., similarity:Contains 5 SH3 domains., subcellular location:Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells., subunit:Interacts with ADAM12, ADAM15 and ADAM19., tissue specificity:Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas., domain:The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19., domain:The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns (3) P) and phosphatidylinositol 3,4-biphosphate (PtdIns (3,4) P2) ., function:Required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns (3) P) and phosphatidylinositol 3,4-biphosphate (PtdIns (3,4) P2) . In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide., PTM:Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR., similarity:Belongs to the SH3PXD2 family., similarity:Contains 1 PX (phox homology) domain., similarity:Contains 5 SH3 domains., subcellular location:Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells., subunit:Interacts with ADAM12, ADAM15 and ADAM19., tissue specificity:Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.
Product Name Alternative
SH3PXD2A; FISH; KIAA0418; SH3MD1; TKS5; SH3 and PX domain-containing protein 2A; Adapter protein TKS5; Five SH3 domain-containing protein; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains
Gene Name
SH3PXD2A
Gene ID
9644
Swiss Prot
Q5TCZ1
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:500, ICC/IF 1:100-1:500, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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