CD158f2 Rabbit Polyclonal Antibody

Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B (KIR2DL5B) Homo sapiens Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) . The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack thefunction:Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis., similarity:Belongs to the immunoglobulin superfamily., similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

KIR2DL5B; CD158F; CD158F2; KIR2DL5; KIR2DLX; Killer cell immunoglobulin-like receptor 2DL5B; CD158 antigen-like family member F2; Killer cell immunoglobulin-like receptor 2DLX; CD antigen CD158f2

KIR2DL5B

553128

Q8NHK3

Human, Rat, Mouse

Unconjugated

WB, ICC/IF, ELISA

Antigen processing and presentation; Natural killer cell mediated cytotoxicity; Graft-versus-host disease

Affinity purification

WB 1:500-1:2000, ICC/IF 1:200-1:1000, ELISA 1:5000-1:20000

Liquid

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Unmodified

40kDa

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.