CD192 Rabbit Polyclonal Antibody

• Background:

  This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009], function:Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection., online information:CC chemokine receptors entry, polymorphism:Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423]., PTM:N-glycosylated., similarity:Belongs to the G-protein coupled receptor 1 family., subunit:Binds to HIV-1 Tat.

• Product Name Alternative:

  CCR2; CMKBR2; C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD192

• Gene Name:

  CCR2

• Gene ID:

  729230

• Swiss Prot:

  P41597

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, ELISA

• Field of Research:

  Cytokine-cytokine receptor interaction; Chemokine

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, ELISA 1:5000-1:20000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  42kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG