Centrobin Rabbit Polyclonal Antibody

• Background:

  This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011], developmental stage:Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases., function:Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., sequence caution:Wrong choice of frame., subcellular location:Centriole-associated, asymmetrically localizes to the daughter centriole., subunit:Interacts with LYST., tissue specificity:Widely expressed (at protein level) . Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.

• Product Name Alternative:

  CNTROB; LIP8; PP1221; Centrobin; Centrosomal BRCA2-interacting protein; LYST-interacting protein 8

• Gene Name:

  CNTROB

• Gene ID:

  116840

• Swiss Prot:

  Q8N137

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, ICC/IF, ELISA

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:5000-1:10000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  100kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG