COMT Rabbit Polyclonal Antibody

CAT: 1444-APRab09227-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab09227-01Size:20 µL
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Background
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT) . The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008], catalytic activity:S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol., cofactor:Binds 1 magnesium ion per subunit., function:Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol., mass spectrometry: PubMed:8020475, online information:Catechol-O-methyl transferase entry, polymorphism:Low enzyme activity alleles are associated with genetic susceptibility to alcoholism [MIM:103780]., polymorphism:Two alleles, COMT*1 or COMT*H with Val-158 and COMT*2 or COMT*L with Met-158 are responsible for a three to four-fold difference in enzymatic activity., PTM:The N-terminus is blocked., similarity:Belongs to the mammalian catechol-O-methyltransferase family., tissue specificity:Brain, liver, placenta, lymphocytes and erythrocytes.
Product Name Alternative
COMT; Catechol O-methyltransferase
Gene Name
COMT
Gene ID
1312
Swiss Prot
P21964
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, ELISA
Field of Research
Steroid hormone biosynthesis; Tyrosine metabolism
Purification
Affinity purification
Dilution
WB 1:500-1:2000, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
30kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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