CD207 Rabbit Polyclonal Antibody

CAT: 1444-APRab08277-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab08277-01Size:20 µL
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Background
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010], function:Calcium-dependent lectin displaying mannose-binding specificity, Induces the formation of Birbeck granules (BGs) ; is a potent regulator of membrane superimposition and zippering., online information:Langerin, similarity:Contains 1 C-type lectin domain., subcellular location:Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes., tissue specificity:Exclusively expressed by Langerhans cells.
Product Name Alternative
CD207; CLEC4K; C-type lectin domain family 4 member K; Langerin; CD207
Gene Name
CD207
Gene ID
50489
Swiss Prot
Q9UJ71
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, ELISA
Purification
Affinity purification
Dilution
WB 1:500-1:2000, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
38kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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