FAST Rabbit Polyclonal Antibody

• Background:

  The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008], catalytic activity:ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]., function:Fas-mediated apoptosis is characterized by FASTK-dephosphorylation and TIA-1-phosphorylation. Both are activated and FASTK-mediated TIA-1 activation play a key role in apoptosis., PTM:Phosphorylated on serine/threonine., similarity:Belongs to the FAST protein kinase family., similarity:Contains 1 RAP domain., subunit:Interacts with TIA-1., tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

• Product Name Alternative:

  FASTK; Fas-activated serine/threonine kinase; FAST kinase

• Gene Name:

  FASTK

• Gene ID:

  10922

• Swiss Prot:

  Q14296

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, ELISA

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, ELISA 1:10000-1:20000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  61kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG