CLIC6 Rabbit Polyclonal Antibody

• Background:

  Chloride intracellular channel 6 (CLIC6) Homo sapiens This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015], domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion., function:May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport., PTM:Phosphorylated., similarity:Belongs to the chloride channel CLIC family., similarity:Contains 1 GST C-terminal domain., subcellular location:Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane., subunit:Interacts with dopamine receptors DRD2, DRD3 and DRD4., tissue specificity:Expressed in brain, placenta, pancreas and liver.

• Product Name Alternative:

  CLIC6; CLIC1L; Chloride intracellular channel protein 6; Parchorin

• Gene Name:

  CLIC6

• Gene ID:

  54102

• Swiss Prot:

  Q96NY7

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, ELISA

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, ELISA 1:20000-1:40000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  75kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG