TPH2 Rabbit Polyclonal Antibody

• Background:

  This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016], catalytic activity:L-tryptophan + tetrahydrobiopterin + O (2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin., cofactor:Fe (2+) ion., disease:Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516]., pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2., similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family., similarity:Contains 1 ACT domain., tissue specificity:Brain specific.

• Product Name Alternative:

  TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2

• Gene Name:

  TPH2

• Gene ID:

  121278

• Swiss Prot:

  Q8IWU9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Monkey

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, ELISA

• Field of Research:

  Tryptophan metabolism

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, ELISA 1:20000-1:40000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  56kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG