Stat6 Rabbit Polyclonal Antibody

• Background:

  The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010], function:Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling., PTM:Tyrosine phosphorylated following stimulation by IL-4 and IL-3., similarity:Belongs to the transcription factor STAT family., similarity:Contains 1 SH2 domain., subcellular location:Translocated into the nucleus in response to phosphorylation., subunit:Forms a homodimer or a heterodimer with a related family member (By similarity) . Interacts with NCOA1 via its C-terminal LXXLL motif.

• Product Name Alternative:

  STAT6; Signal transducer and activator of transcription 6; IL-4 Stat

• Gene Name:

  STAT6

• Gene ID:

  6778

• Swiss Prot:

  P42226

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Monkey

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC, ICC/IF, ELISA

• Field of Research:

  Jak_STAT

• Purification:

  Affinity purification

• Dilution:

  WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:5000-1:10000

• Form:

  Liquid

• Buffer:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

• Modification:

  Unmodified

• Molecular Weight:

  94kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.

• Isotype:

  IgG