CD71 Rabbit Polyclonal Antibody

CAT: 1444-APRab08446-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab08446-01Size:20 µL
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Background
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015], function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site., induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation., miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells., miscellaneous:Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients., PTM:N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated., PTM:Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation., PTM:Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR) ., similarity:Belongs to the peptidase M28 family. M28B subfamily., similarity:Contains 1 PA (protease associated) domain., subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., subunit:Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.
Product Name Alternative
TFRC; Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71
Gene Name
TFRC
Gene ID
7037
Swiss Prot
P02786
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
Endocytosis; Hematopoietic cell lineage
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
85kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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