COL5A1 Rabbit Polyclonal Antibody

CAT: 1444-APRab09191-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab09191-01Size:20 µL
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Background
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1 (V) -pro-alpha1 (V) -pro-alpha2 (V) . Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013], disease:Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome., disease:Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 2 (EDS2) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome., function:Type V collagen is a member of group I collagen (fibrillar forming collagen) . It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin., PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains., PTM:Sulfated on 40% of tyrosines., similarity:Belongs to the fibrillar collagen family., similarity:Contains 1 laminin G-like domain., similarity:Contains 1 TSP N-terminal (TSPN) domain., subunit:Trimers of two alpha 1 (V) and one alpha 2 (V) chains in most tissues and trimers of one alpha 1 (V), one alpha 2 (V), and one alpha 3 (V) chains in placenta. Interacts with CSPG4.
Product Name Alternative
COL5A1; Collagen alpha-1 (V) chain
Gene Name
COL5A1
Gene ID
1289
Swiss Prot
P20908
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
Focal adhesion; ECM-receptor interaction
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:200-1:1000, ELISA 1:10000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
200kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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