E-Selectin Rabbit Polyclonal Antibody

The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008], function:Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis., online information:E-selectin, polymorphism:A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD) . A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149) ., similarity:Belongs to the selectin/LECAM family., similarity:Contains 1 C-type lectin domain., similarity:Contains 1 EGF-like domain., similarity:Contains 6 Sushi (CCP/SCR) domains., subunit:Interacts with PSGL1/SELPLG through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.

Selectin E

SELE ELAM1

6401

P16581

Human, Rat, Mouse

Unconjugated

WB, IHC, ICC/IF, ELISA

Cell adhesion molecules (CAMs)

Affinity purification

WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:10000-1:20000

Liquid

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Unmodified

66kDa

Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.