AF10 Rabbit Monoclonal Antibody

• Background:

  Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302) .

• Product Name Alternative:

  MLLT10; AF10; Protein AF-10; ALL1-fused gene from chromosome 10 protein

• Gene Name:

  AF10

• Gene ID:

  8028

• Swiss Prot:

  P55197

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC

• Purification:

  Affinity Purification

• Dilution:

  WB 1:500-1:1000, IHC 1:50-1:100

• Form:

  Liquid

• Buffer:

  Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

• Modification:

  Unmodified

• Molecular Weight:

  Calculated MW: 113 kDa; Observed MW: 140 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Isotype:

  IgG