Recombinant Human IL-23

• Background :

  Interleukin-23 (IL-23) is a heterodimeric cytokine that belongs to the IL-12 cytokine family. It is composed of two subunits, p19 and p40, with the p40 subunit being shared with IL-12. IL-23 is primarily secreted by activated macrophages and dendritic cells located in peripheral tissues such as skin, intestinal mucosa, and lung. This cytokine plays a crucial role in the development and maintenance of autoimmune inflammation, particularly through its ability to induce IL-17 production, which is a unique role compared to IL-12.

• Product Name Alternative :

  SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2

• Accession Number :

  P29460 (P40), AAG37232 (P19)

• Host :

  Human Cells

• Endotoxin :

  ≤10 EU/mg

• Purity :

  Greater than 95% as determined by reducing SDS-PAGE

• Form :

  Lyophilized

• Reconstitution :

  Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

• Molecular Weight :

  55.0 kDa (IL-23singlechain) ;36.5 kDa (p40) &18.5 kDa (p19)

• Shipping Conditions :

  The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

• Storage Conditions :

  Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

• Formulation :

  Lyophilized From PBS,5% mannitol and 0.01% Tween 80, pH7.4

• Construct :

  Recombinant Human IL-23 is produced by our Mammalian cell expression system and the target gene encoding Ile23-Ser328&Arg23-Pro189 is expressed.

• Species :

  Human