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Recombinant Human IL-23

CAT: 1444-PCH2527-01Size: 1 EachDry Ice: YesHazardous: No
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CAT#:1444-PCH2527-01Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-23 (IL-23) is a heterodimeric cytokine that belongs to the IL-12 cytokine family. It is composed of two subunits, p19 and p40, with the p40 subunit being shared with IL-12. IL-23 is primarily secreted by activated macrophages and dendritic cells located in peripheral tissues such as skin, intestinal mucosa, and lung. This cytokine plays a crucial role in the development and maintenance of autoimmune inflammation, particularly through its ability to induce IL-17 production, which is a unique role compared to IL-12.
Product Name Alternative
SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2
Accession Number
P29460 (P40), AAG37232 (P19)
Host
Human Cells
Endotoxin
≤10 EU/mg
Purity
Greater than 95% as determined by reducing SDS-PAGE
Form
Lyophilized
Reconstitution
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Molecular Weight
55.0 kDa (IL-23singlechain) ;36.5 kDa (p40) &18.5 kDa (p19)
Shipping Conditions
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Formulation
Lyophilized From PBS,5% mannitol and 0.01% Tween 80, pH7.4
Construct
Recombinant Human IL-23 is produced by our Mammalian cell expression system and the target gene encoding Ile23-Ser328&Arg23-Pro189 is expressed.
Species
Human

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