Recombinant Human IL-4

• Background :

  Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response.

• Product Name Alternative :

  Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4

• Accession Number :

  P05112

• Host :

  Human Cells

• Endotoxin :

  ≤10 EU/mg

• Purity :

  Greater than 95% as determined by reducing SDS-PAGE

• Form :

  Lyophilized

• Reconstitution :

  Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

• Molecular Weight :

  15 kDa

• Shipping Conditions :

  The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

• Storage Conditions :

  Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

• Formulation :

  Lyophilized From PBS,5% mannitol and 0.01% Tween 80, pH7.4

• Construct :

  Recombinant Human IL-4 is produced by our Mammalian cell expression system and the target gene encoding His25-Ser153 is expressed.

• Species :

  Human