Products for Research Use Only
RegisterLogin

Recombinant Human Neurturin

CAT: 1444-PEH1218-01Size: 10 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1444-PEH1218-01Size:10 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. Neurturin is expressed in both neuronal and nonneuronal tissues. Similarly to other TGFβ family proteins, Neurturin is synthesized as a precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. The carboxy terminal domain of Neurturin contains the characteristic seven conserved cysteine residues necessary for the formation of the cysteine-knot and the single interchain disulfide bond. Biologically active human Neurturin is a disulfide-linked homodimer of the carboxy-terminal 102 amino acid residues. Unlike other members of TGF-β family, bioactivities of all GDNF family ligands are mediated through a unique multicomponent receptor complex composed of high affinity ligand binding component (GFRα-1-GFRα-4) and a common signaling component (cRET receptor tyrosine kinase) . Each member of the GDNF family ligands has its preferred binding protein. Neurturin preferentially binds to GFRα-2 but can also bind GFRα-1 at higher concentrations. It may play a role in regulating the development and maintenance of the central and peripheral nervous systems and as well as non neuronal systems.
Product Name Alternative
Neurturin; NRTN
Accession Number
Q99748
Host
E.coli
Endotoxin
<1 EU/µg as determined by LAL test.
Purity
Greater than 95% as determined by reducing SDS-PAGE
Form
Lyophilized
Reconstitution
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Molecular Weight
11.8 KDa
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Formulation
Lyophilized from a 0.2 μm filtered solution of 20mM Citrate, 6% Sucrose, 4% Mannitol, 0.05% Tween 80, pH 4.0.
Construct
Recombinant Human Neurturin is produced by our E.coli expression system and the target gene encoding Ala96-Val197 is expressed.
Species
Human

Related Products

CatalogName
EH25027Human NRTN (Neurturin) ELISA Kit
PCH2530-01Recombinant Human LIF
PCH2504-01Recombinant Human EPO
PCH2503-01Recombinant Human EGF
PCH2500-01Recombinant Human Activin A
PEH1312-01Recombinant Human Persephin
PEH0273-01Recombinant Human CCL8
PEH0270-01Recombinant Human CCL3
PEH0268-01Recombinant Human CCL27
PEH0259-01Recombinant Human CCL11

Alternative Products

CatalogName
P1315-.1Recombinant Human Neurturin
rAP-2706Neurturin Human Recombinant
TMPJ-01290-01Neurturin Protein, Human, Recombinant
NBP2-61320-500ugRecombinant Human Neurturin Protein
MBS650414-01Neurturin, Recombinant, Human (NTN)
MBS1305325-01Recombinant Human Neurturin (NRTN)

Popular Products