Recombinant Human CD38 (C-mFc)

• Background :

  CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells.

• Product Name Alternative :

  ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10

• Accession Number :

  P28907

• Host :

  Human Cells

• Endotoxin :

  <1 EU/µg as determined by LAL test.

• Purity :

  Greater than 95% as determined by reducing SDS-PAGE

• Form :

  Lyophilized

• Reconstitution :

  Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

• Molecular Weight :

  56.5 KDa

• Shipping Conditions :

  The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

• Storage Conditions :

  Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

• Formulation :

  Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

• Construct :

  Recombinant Human ADP-ribosyl Cyclase/cyclic ADP-ribose Hydrolase 1 is produced by our Mammalian expression system and the target gene encoding Val43-Ile300 is expressed with a mouse IgG1 Fc tag at the C-terminus.

• Species :

  Human