Recombinant Mouse LMIR1 (C-Fc)

• Background:

  LMIR1, also termed CD300a, is a type I transmembrane glycoprotein with a single IgV-like extracellular domain and an extended membrane proximal region that links the immunoglobulin (Ig) and transmembrane domains and belongs to the immunoglobulin superfamily. The intracellular domain of LMIR1 contains several immunoreceptor tyrosine-based inhibition motifs (ITIMs) . When cross-linked, it will be tyrosine phosphorylated and capable of recruiting tyrosine phosphatases (SHP-1, SHP-2) and inositol polyphosphate 5-phosphatase, SHIP. LMIR1 will regulate mast cell-mediated inflammatory responses. LMIR1 is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type.

• Product Name Alternative:

  CD300a; CD300a antigen; CMRF35H9; CD300a molecule; leukocyte immunoglobulin-like receptor; CD300 antigen-like family member A; CMRF35-like molecule 8; NK inhibitory receptor; Immunoglobulin superfamily member 12; IRp60; Inhibitory receptor protein 60; CLM8; CMRF-35H; IGSF12; IRC1; IRC2; LMIR1; CLM-8; MAIR-I

• Accession Number:

  Q6SJQ0

• Host:

  Human Cells

• Endotoxin:

  <1 EU/µg as determined by LAL test.

• Purity:

  Greater than 95% as determined by reducing SDS-PAGE

• Form:

  Lyophilized

• Reconstitution:

  Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

• Molecular Weight:

  44.3 KDa

• Shipping Conditions:

  The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

• Storage Conditions:

  Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

• Formulation:

  Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

• Construct:

  Recombinant Mouse Leukocyte Mono-Ig-like Receptor 1 is produced by our Mammalian expression system and the target gene encoding Leu28-Arg183 is expressed with a human IgG1 Fc tag at the C-terminus.

• Species:

  Mouse