Recombinant Mouse ST6GalNAc2 (C-6His)

• Background:

  Alpha‑N‑acetylgalactosaminide alpha ‑2,6‑sialyltransferase 2, is a type/xa0II membrane protein localized in the Golgi network and catalyzes 2,6‑sialylation of the Tn antigen. Sialyl‑Tn antigen is highly expressed in several human carcinomas and is associated with carcinoma aggressiveness and poor prognosis./xa0it has been reported that disregulation of this gene is involved in the pathogenesis of IgA nephropathy, a common kidney disease that occurs when antibody IgA accumulates in kidneys (4) . The enzyme may also be used to synthesize a cancer vaccine.

• Product Name Alternative:

  Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase, GalNAc alpha-2,6-sialyltransferase II, ST6GalNAc II, Sialyltransferase 7B, SIAT7-B

• Accession Number:

  P70277

• Host:

  Human Cells

• Endotoxin:

  <1 EU/µg as determined by LAL test.

• Purity:

  Greater than 95% as determined by reducing SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  40.4 KDa

• Shipping Conditions:

  The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

• Storage Conditions:

  Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

• Formulation:

  Supplied as a 0.2 μm filtered solution of 50mMTris-HCl, 150mM NaCl, pH 7.5.

• Construct:

  Recombinant Mouse Alpha-N-acetylgalactosaminide Alpha-2,6-sialyltransferase 2 is produced by our Mammalian expression system and the target gene encoding Ser28-Arg373 is expressed with a 6His tag at the C-terminus.

• Species:

  Mouse