Recombinant Human Kell (C-6His)

• Background:

  Kell blood group glycoprotein (KEL) is a single-pass type II membrane protein which belongs to the peptidase M13 family. It is expressed in Expressed at high levels in erythrocytes and testis, and, at lower levels, in skeletal muscle, tonsils, lymph node, spleen and appendix. KEL has been shown zinc endopeptidase with endothelin-3-converting enzyme activity. It cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. It links via a single disulfide bond to the XK membrane protein that carries the Kx antigen.

• Product Name Alternative:

  Kell blood group glycoprotein; CD238; KEL

• Accession Number:

  P23276

• Host:

  Human Cells

• Endotoxin:

  <1 EU/µg as determined by LAL test.

• Purity:

  Greater than 95% as determined by reducing SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  76.4 KDa

• Shipping Conditions:

  The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

• Storage Conditions:

  Store at -70°C/-20°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

• Formulation:

  Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

• Construct:

  Recombinant Human Kelch-like Protein 41 is produced by our Mammalian expression system and the target gene encoding Asn68-Trp732 is expressed with a 6His tag at the C-terminus.

• Species:

  Human