Products for Research Use Only
RegisterLogin

ADL5859

CAT: 0804-HY-14356Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14356Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ADL-5859 is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM, respectively. ADL-5859 also shows inhibitory activity to hERG channel with an IC50 value of 78 μM. ADL-5859 can be used for the research of pain[1][2].
CAS Number
850305-06-5
UNSPSC
12352005
Target
Cytochrome P450; Opioid Receptor; Potassium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/adl5859.html
Smiles
O=C(N(CC)CC)C1=CC=C(C2=CC3(CCNCC3)OC4=C2C(O)=CC=C4)C=C1
Molecular Formula
C24H28N2O3
Molecular Weight
392.49
References & Citations
[1]Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N, N-Diethyl-4- (5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl) benzamide (ADL5859) J. Med. Chem., 2008, 51 (19), pp 5893-5896|[2]Le Bourdonnec B, et al. Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N, N-diethyl-4- (5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5859) . J Med Chem. 2008 Oct 9;51 (19) :5893-6.|[3]Le Bourdonnec B, et al. Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N, N-diethyl-3-hydroxy-4- (spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747) .J Med Chem. 2009 Sep 24;52 (18) :5685-702.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
GTR19161458-01ADL5859
A2986-25ADL5859 HCl
MBS578740ADL5859 hydrochloride
A11072-25ADL5859 HCl 25mg
A11072-50ADL5859 HCl 50mg
A11072-10ADL5859 HCl 10mg
A11072-2ADL5859 HCl 2mg
A11072-500ADL5859 HCl 500mg
A11072-100ADL5859 HCl 100mg
A11072-5ADL5859 HCl 5mg

Popular Products