Phleomycin

• Description :

  Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Antibiotic; Bacterial; DNA/RNA Synthesis

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/phleomycin.html

• Purity :

  95.0

• Solubility :

  H2O : 100 mg/mL (ultrasonic)

• Smiles :

  [Phleomycin]

• Precautions :

  H302

• References & Citations :

  [1]Kamila Stokowa-Sołtys, et al. Phleomycin complex-Coordination mode and in vitro cleavage of DNA. J Inorg Biochem. 2019 Jun;195:71-82.|[2]van Peer AF, et al. Phleomycin increases transformation efficiency and promotes single integrations in Schizophyllum commune. Appl Environ Microbiol. 2009 Mar;75 (5) :1243-7.|[3]TANAKA N, et al. Mechanism of action of phleomycin, a tumor-inhibitory antibiotic. Biochem Biophys Res Commun. 1963 Jan 31;10:171-4.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Glycopeptide

• CAS Number :

  [11006-33-0]