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Asnuciclib

CAT: 0804-HY-12445-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12445-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Asnuciclib (CDKI-73; LS-007) is an orally active and highly efficacious CDK9 inhibitor, with Ki values of 4 nM, 4 nM and 3 nM for CDK9, CDK1 and CDK2, respectively. Asnuciclib down-regulates the RNAPII phosphorylation. Asnuciclib is also a novel pharmacological inhibitor of Rab11 cargo delivery and innate immune secretion[1][2][3][4].
CAS Number
1421693-22-2
Product Name Alternative
CDKI-73; LS-007
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/asnuciclib.html
Purity
99.76
Solubility
DMSO : ≥ 52 mg/mL
Smiles
CNC1=NC(C)=C(C2=C(F)C=NC(NC3=CC(S(=O)(N)=O)=CC=C3)=N2)S1
Molecular Formula
C15H15FN6O2S2
Molecular Weight
394.45
Precautions
H302, H315, H319
References & Citations
[1]Lam F, et al. Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73. Oncotarget. 2014 Sep 15;5 (17) :7691-704.|[2]Elisabeth Walsby, et al. A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine. Oncotarget. 2014 Jan; 5 (2) : 375–385.|[3]Muhammed H Rahaman, et al. CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia. Invest New Drugs. 2019 Aug;37 (4) :625-635.|[4]Alexandra Sorvina, et al. CDKI-73 is a Novel Pharmacological Inhibitor of Rab11 Cargo Delivery and Innate Immune Secretion. Cells. 2020 Feb 5;9 (2) :372.|[5]Shao Xie, et al. Antitumor action of CDK inhibitor LS-007 as a single agent and in combination with ABT-199 against human acute leukemia cells. Acta Pharmacol Sin. 2016 Nov; 37 (11) : 1481–1489.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK4; CDK6; CDK7; CDK9

Alternative Products

CatalogName
A21467-25Asnuciclib (CDKI-73) 25mg
A21467-100Asnuciclib (CDKI-73) 100mg
A21467-10Asnuciclib (CDKI-73) 10mg
A21467-5Asnuciclib (CDKI-73) 5mg
A21467-50Asnuciclib (CDKI-73) 50mg
A21467-2Asnuciclib (CDKI-73) 2mg
A21467-1Asnuciclib (CDKI-73) 1mg
A21467-10mM-DAsnuciclib (CDKI-73) 10mM * 1mL in DMSO

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