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Kaempferide

CAT: 0804-HY-15449-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15449-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research[1][2][3][4][5][6].
CAS Number
491-54-3
Product Name Alternative
Kaempferol 4'-O-methyl ether
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; Apoptosis; Autophagy; Bacterial; Estrogen Receptor/ERR; FOXO; GSK-3; Influenza Virus; PI3K; β-catenin
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kaempferide.html
Concentration
10mM
Purity
99.80
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C1C(O)=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13
Molecular Formula
C16H12O6
Molecular Weight
300.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Chandrababu G, et al. Kaempferide exhibits an anticancer effect against hepatocellular carcinoma in vitro and in vivo[J]. Naunyn-Schmiedeberg's Archives of Pharmacology, 2023: 1-7.|[2]Tie F, et al. Kaempferol and kaempferide attenuate oleic acid-induced lipid accumulation and oxidative stress in HepG2 cells[J]. International Journal of Molecular Sciences, 2021, 22 (16) : 8847.|[3]Ma X, et al. Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β-catenin signaling pathway[J]. European Journal of Pharmacology, 2021, 911: 174555.|[4]Tang H, et al. Kaempferide improves oxidative stress and inflammation by inhibiting the TLR4/IκBα/NF-κB pathway in obese mice[J]. Iranian Journal of Basic Medical Sciences, 2021, 24 (4) : 493.|[5]Wang D, et al. Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3β Pathway. Mediators Inflamm. 2017;2017:5278218. |[6]Nath L R, et al. Kaempferide, the most active among the four flavonoids isolated and characterized from Chromolaena odorata, induces apoptosis in cervical cancer cells while being pharmacologically safe[J]. RSC advances, 2015, 5 (122) : 100912-100922.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
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