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Fadrozole

CAT: 0804-HY-14247A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14247A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fadrozole (CGS 16949A free base) is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.
CAS Number
102676-47-1
Product Name Alternative
CGS 16949A (free base) ; (Rac) -FAD286
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Fadrozole.html
Concentration
10mM
Purity
99.78
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N#CC1=CC=C(C2CCCC3=CN=CN23)C=C1
Molecular Formula
C14H13N3
Molecular Weight
223.28
Precautions
H315, H319, H335
References & Citations
[1]Browne LJ, et al. Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem. 1991 Feb;34 (2) :725-36.|[2]Gunson DE, et al. Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor. Br J Cancer. 1995 Jul;72 (1) :72-5.|[3]Morales-Montor J, et al. Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis. Int J Parasitol. 2002 Oct;32 (11) :1379-87.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Aromatase/CYP19A1
Citation 01
Ecotoxicol Environ Saf. 2021 Apr 1:212:111991.|Dis Model Mech. 2024 Oct 1;17 (10) :dmm050900.

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