Bayer-18

• Description:

  Bayer-18 is an inhibitor for TYK2. Bayer-18 inhibits the viability of ALCL cell K299, SR786, Mac1 and Mac2a with IC50 of 2-3 µM, and induces apoptosis in K299 and SR786[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; JAK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bayer-18.html

• Purity:

  99.51

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C (NC (C) (C) C) NC1=CC=CC (NC2=NC=C (C (NC (C) (CO) C) =N2) F) =C1

• Molecular Formula:

  C19H27FN6O2

• Molecular Weight:

  390.46

• References & Citations:

  [1]Prutsch N, et al., Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma. Leukemia. 2019 Mar;33 (3) :696-709. doi: 10.1038/s41375-018-0239-1. Epub 2018 Aug 21. Erratum in: Leukemia. 2020 Nov;34 (11) :3105.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Tyk2

• CAS Number:

  1251752-12-1