Bayer-18

CAT: 0804-HY-18315-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18315-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bayer-18 is an inhibitor for TYK2. Bayer-18 inhibits the viability of ALCL cell K299, SR786, Mac1 and Mac2a with IC50 of 2-3 µM, and induces apoptosis in K299 and SR786[1].
CAS Number
[1251752-12-1]
UNSPSC
12352005
Target
Apoptosis; JAK
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bayer-18.html
Purity
99.51
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC(C)(C)C)NC1=CC=CC(NC2=NC=C(C(NC(C)(CO)C)=N2)F)=C1
Molecular Formula
C19H27FN6O2
Molecular Weight
390.46
References & Citations
[1]Prutsch N, et al., Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma. Leukemia. 2019 Mar;33 (3) :696-709. doi: 10.1038/s41375-018-0239-1. Epub 2018 Aug 21. Erratum in: Leukemia. 2020 Nov;34 (11) :3105.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Tyk2

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