Osthole

CAT: 0804-HY-N0054-01Size: 250 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0054-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.
CAS Number
[484-12-8]
Product Name Alternative
Osthol; NSC 31868
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HBV; Histamine Receptor; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Endocrinology; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Osthole.html
Purity
99.94
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C=CC2=CC=C(OC)C(C/C=C(C)\C)=C2O1
Molecular Formula
C15H16O3
Molecular Weight
244.29
Precautions
H302, H315, H319, H335
References & Citations
[4]Zhang ZR, et al. Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine. Evid Based Complement Alternat Med. 2015;2015:919616.|[1]Kordulewska NK, et al. Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients. Immunobiology.|[2]Tang DZ, et al. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res. 2010 Jun;25 (6) :1234-45.|[3]Sun W, et al. Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways. Acta Pharmacol Sin. 2017 Aug;38 (8) :1120-1128.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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