Osthole

• Description :

  Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.

• Product Name Alternative :

  Osthol; NSC 31868

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; HBV; Histamine Receptor; Parasite

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection; Endocrinology; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Osthole.html

• Purity :

  99.94

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C1C=CC2=CC=C(OC)C(C/C=C(C)\C)=C2O1

• Molecular Formula :

  C15H16O3

• Molecular Weight :

  244.29

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [4]Zhang ZR, et al. Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine. Evid Based Complement Alternat Med. 2015;2015:919616.|[1]Kordulewska NK, et al. Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients. Immunobiology.|[2]Tang DZ, et al. Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res. 2010 Jun;25 (6) :1234-45.|[3]Sun W, et al. Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways. Acta Pharmacol Sin. 2017 Aug;38 (8) :1120-1128.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [484-12-8]